Tobacco-specific nitrosamines in smokeless tobacco products marketed in India

Tobacco-specific nitrosamines in new tobacco products.

New tobacco products, designed to attract consumers who are concerned about the health effects of tobacco, have been appearing on the market. Objective evaluation of these products requires, as a first step, data on their potentially toxic constituents. Tobacco-specific nitrosamines (TSNAs) are an important class of carcinogens in tobacco products, but virtually no data were available on their ...

Assessment of tobacco-specific N-nitrosamines in tobacco products.

lengthy enrichment procedures in earlier studies. The highly sensitive and specific TEA (7) simplifies the quantitative deter mination of nitrosamines, in that these nonvolatile compounds need only be concentrated once prior to separation by HPLC and detection. For an accurate measurement of these nitrosamines in chew ing tobacco, tobacco leaves, and unaged smoke, extraction procedures as well ...

SMOKELESS TOBACCO SMOKELESS TOBACCO 1. Description of Smokeless Tobacco Practices

Tobacco-specific nitrosamines and their pyridine-N-glucuronides in the urine of smokers and smokeless tobacco users.

Tobacco-specific nitrosamines are believed to play a significant role as causes of cancer in people who use tobacco products. Whereas the uptake of one tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, has been shown by analysis of its metabolites in urine, there are no published studies on urinary levels of N'-nitrosonornicotine (NNN), N'-nitrosoanatabine (NAT), and...

Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines.

OBJECTIVE Oral tobacco products contain nicotine and carcinogenic tobacco-specific N-nitrosamines (TSNAs) that can be absorbed through the oral mucosa. The aim of this study was to determine typical pH ranges and concentrations of total nicotine, unionised nicotine (the most readily absorbed form) and five TSNAs in selected oral tobacco products distributed globally. METHODS A total of 53 ora...